Mitochondriale Logistik: Assemblierung der Cytochrom- c -Oxidase

Mitochondrial respiratory-chain complexes assemble from subunits either translated in mitochondria or imported from the cytosol. In the early steps of respiratory chain biogenesis, specific assembly factors participate in the formation of assembly intermediates of the individual complexes. These intermediates play a critical role in feedback regulation of mitochondrial protein synthesis in response to the assembly state.