PS18 - 89. β-cell adaptation is heterogeneous in response to insulin resistance

Rianne Ellenbroek,Annemieke Töns,Cindy Loomans,Marten Engelse,Hans Vrolijk,Ton Rabelink,Françoise Carlotti,Eelco de Koning

Nederlands Tijdschrift voor Diabetologie（2015）

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摘要

Insulin resistance leads to islet adaptation characterized by increased insulin production in order to maintain normoglycemia. The mechanism of this adaptation is unclear. Increased insulin production can be achieved by augmenting insulin secretion from individual β-cells and/or increasing β-cell number.

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关键词

Insulin Resistance,Insulin Secretion,Insulin Tolerance Test,Induce Insulin Resistance,Islet Isolation

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