Synergic Antitumor And Antitoxicity Effects Of The Traditional Uyghur Medicine Abnormal Savda Munziq When Combined With 5-Fluorouracil

Objective: A number of traditional Uyghur medicines have been recognized as potent antitumor agents and have been developed and analyzed in vivo. In the present study, the toxic, therapeutic and cytotoxic properties of the Uyghur medicine Abnormal Savda Munziq (ASMq) were investigated. In the presence of certain agents, ASMq results in the fragmentation of plasmid DNA, indicating that it may be a potent antitumor agent in vivo, as it appears to bind to DNA molecules. Thus, the present study investigated the effects of ASMq in combination with 5-fluorouracil (5-FU) in vivo, using an S180 mouse model of cancer. ASMq was observed to enhance the antitumor effect of 5-FU and also attenuated the cytotoxicity of the oxidative stress reactions. Methods: The mice were divided randomly into six groups. Influence of treatment on the activity of mice were observed. The serum levels of SOD, MDA, GSH-Px and pathological change were determined. Results: Compared with the model group, the data turned normal after gavaged 5-FU and ASMq. Conclusion: In summary, a combination of ASMq and 5-FU resulted in a synergistic antitumor effect and attenuated toxicity, suggesting that ASMq may be clinically applicable for the treatment of certain types of cancer.