Induction of potent systemic anti-melanoma immunity through intratumoral CD40 activation and checkpoint blockade

Manisha Singh,Zhimin Dai,Hiep Khong,Christina Vianden,Mark Cantwell,Willem Overwijk

Journal for ImmunoTherapy of Cancer（2015）

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摘要

Meeting abstracts Agonistic CD40 antibodies generate strong tumor specific CD8 T cell response and anti-tumor activity; however systemic anti-CD40 therapy has been associated with cytokine release syndrome and liver toxicity. We studied the anti-melanoma activity and mechanism of action of a

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关键词

Melanoma, Cytokine Release Syndrome, Agonistic CD40, Agonistic CD40 Antibody, Checkpoint Blockage

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