Mechanism evaluation of the interactions between flavonoids and bovine serum albumin based on multi-spectroscopy, molecular docking and Q-TOF HR-MS analyses

Ling Fu,Yiqun Sun,Lina Ding,Yangyang Wang, Zhen Gao, Zhen Wu,Shaomin Wang,Wen Li,Yuefeng Bi

Food Chemistry（2016）

Cited 56|Views7

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Abstract

•Q-TOF HR-MS were used to research the interaction between flavonoids and BSA.•Different substituent groups such as methoxyl on the A, B ring of flavonoid.•Fluorescence suggested the chain structure of BSA was altered after binding.•Fluorescence and docking suggested substituent locations would affect interaction.

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Key words

Luteolin (PubChem CID: 5280445),Apigenin (PubChem CID: 5280443),Acacetin (PubChem CID: 5280442),Tricin (PubChem CID: 5281702),5,3′,4′-Trihydroxy-6,7-dimethoxyflavone (CAS 34334-69-5),5,7,4′-Trihydroxy-6,3′,5′-trimethoxyflavone (CAS 76015-42-4),Linarin (PubChem CID: 5317025)

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