Development of risug® derivative as an effective antimicrobial compound that can be coated onto urinary catheters for prevention of bacterial biofilms

Bacterial colonization on implant surface leads to implant associated infection. These infections limit the long term benefits of medical implanted devices and also act as a source of continues chronic microbial load in catheterized individual. Alteration of surface properties has been a lucrative option for prevention of development of microbial aggregates on implant materials. In the present study application of styrene maleic anhydride (SMA) in combination with DMSO has been carried out for coating the Foley’s catheter for prevention of bacterial adhesion. Drug coated polymer was found to be highly hemo-compatible in nature. A significant decrease in numbers of adhered bacteria was observed after microscopic evaluation of the surface. Further, SMA-DMSO complex led to bacterial killing, induced by blebbing and disintegration of bacterial cells. Lipid peroxidation of drug treated bacterial cells was also observed. The present study reports safe and effective coating of SMA-DMSO complex onto urinary catheter leading to prevention of bacterial adhesion.