Effect Of Drd2/Ankk1 Taqia Allelic Polymorphism On The Risk And Prognosis Of Cervical Precancer And Cancer

Objectives: The aim of this study was to elucidate the role of dopamine receptor D2 / ankyrin repeat and protein kinase domain containing 1 (DRD2/ANKK1) TaqIA allelic polymorphism in the HPV-induced cervical carcinogenesis.Methods: 1. Effect on the risk of cervical precancer: After an 8-year follow-up, out of 214 women with persisting high-risk HPV infection, 102 developed high-grade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade III, while 112 did not. The subjects were genotyped for the DRD2/ANKK1 TaqIA polymorphism by PCR-RFLP, and the allelic distributions were compared between groups with and without high-grade dysplasia. 2. Prognostic value: Two hundred and thirty nine women with cervical precancer/cancer were followed for 5 years. Complete remission was achieved at 182 women. To assess the prognostic value of the TaqIA polymorphism, genotype frequencies were compared between patients reaching and not reaching complete remission.Results: The frequency of A1/A1+A1/A2 genotypes was higher among women who developed high-grade cervical dysplasia (OR: 1.87, 95% CI: 1.05-3.33; p=0.034) than in the other group. Occurrence of the A1 allele was more frequent among women who did not reach complete remission (OR: 2.00, 95% CI: 1.07-3.74; p=0.030) than in women with complete remission.Conclusions: This is the first report on the possible involvement of DRD2/ANKK1 TaqIA polymorphism in cervical carcinogenesis. The A1 allele seems to increase the risk of cervical precancer, and it may also be associated with a worse prognosis in women with HPV-induced cervical cancer. The results need further validation in large-scale molecular epidemiological studies.