Comparative Study on The Potency of Antibiotic Discs With Commercially Sold Antibiotics on Clinical Isolates From Urinary Tract

A total of 250 urine samples were collected from patients attending Ahmadu Bello University Health Service Clinic (Sick bay), Salama Hospital and Major Ibrahim Abdullahi Memorial Hospital (Kaduna State Ministry of Health). The samples were screened for UTI and forty-three (43) were positive for Klebsiella and Escherichia coli . Of all the isolates, 24 were K. species and 19 were Escherichia coli. Their susceptibilities to Ampicillin, Ciprofloxacin and Gentamicin were examined using the antibiotics disc and the commercially sold antibiotics. The susceptibility of K. species to Ampicillin, Ciprofloxacin and Gentamicin for the antibiotics disc was 16.7%, 62.5% and 41.7% respectively. For the commercially sold antibiotics its susceptibility was 0%, 8.3% and 50.0% to Ampicillin, Ciprofloxacin and Gentamicin respectively. The susceptibility of Escherichia coli to Ampicillin, Ciprofloxacin and Gentamicin for the antibiotics disc was 31.6%, 52.6% and 57.9% respectively. For the commercially sold antibiotics its susceptibility was 0%, 36.8% and 31.6% to Ampicillin, Ciprofloxacin and Gentamicin respectively. Our results showed that antibiotics disc was more effective than the commercially sold antibiotics and that both organisms were resistant to Ampicillin but susceptible to Gentamicin and Ciprofloxacin. Keywords : Potency, Antibiotics, Disc Isolates, Urinary tract Nigerian Journal of Basic and Applied Science (2011), 19(2):231- 235