An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine
RSC ADVANCES(2015)
Abstract
A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations include proline catalyzed aminoxylation, Corey-Fuchs protocol, Sonogashira coupling and intramolecular Mitsunobu reactions.
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Key words
tetrahydroquinolines,enantioselective approach,total synthesis
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