We report the first observation of the decay D+ -> eta'e(+)v(e) in two analyses, which combined provide a branching fraction of B(D+ -> eta'e(+)v(e)) = (2.16 +/- 0.53 +/- 0.07) x 10(-4). We also provide an improved measurement of B(D+ -> eta'e(+)v(e)) = 11.4 +/- 0.9 +/- 0.4) x 10(-4), provide the first form factor measurement, and set the improved upper limit B(D+ -> phi(+)(e)v(e)) < 0.9 x 10(-4) ( 90% C. L.).