Importin-Alpha 7 Is Involved In The Formation Of Ebola Virus Inclusion Bodies But Is Not Essential For Pathogenicity In Mice
JOURNAL OF INFECTIOUS DISEASES(2015)
摘要
Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-alpha isoforms. Thereby, it blocks STAT1-mediated IFN-alpha/beta and IFN-gamma synthesis. However, owing to the lack of importin-alpha knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-alpha 7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-alpha 7 was not sufficient to increase survival rates among mice infected with EBOV.
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关键词
Ebola virus, importin-alpha, inclusion bodies, pathogenicity, VP24, interferon, STAT1
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