Resting State Functional Near Infrared Spectroscopy

The present study investigated the spatial-temporal variation of oxygenated hemoglobin (HbO), deoxygenated hemoglobin (Hb), blood volume (BV) and blood oxygenation (BO) concentration changes in the prefrontal cortex, measured with functional near-infrared spectroscopy (fNIRS) during resting state. We examined 36 healthy right handed subjects seating with their minds and body quiet and still, as well as their eyes closed for 5 minutes. The spatial mean concentration change of the four estimated parameters across subjects was found near zero; Moreover, the mean concentration changes across subjects for HbO and Hb were found to be more reduced than those of BV and BO. In addition, there were no statistically voxelwise significant differences for the mean concentration changes related to HbO, Hb, BV, neither BO; this finding strongly suggests for a spatial stability in the mean concentration changes during resting state.