Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers

Chen Gao,Zhini He,Jie Li,Xiao Li,Qing Bai,Zhengbao Zhang,Xiao Zhang,Shan Wang,Xinhua Xiao,Fangping Wang,Yan Yan,Daochuan Li,Liping Chen,Xiaowen Zeng,Yongmei Xiao,Guanghui Dong,Yuxin Zheng,Qing Wang,Wen Chen

Toxicology Reports（2016）

引用 34|浏览23

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摘要

•HOTAIR and MALAT1 were upregulated in PBLCs of PAHs-exposed workers.•HOTAIR and MALAT1 expression was positively associated with the degree of DNA damage induced by PAHs.•H3K27me3 modification was positively correlated with the degree of genetic damage and the increase of HOTAIR expression.

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关键词

PAHs,PBLCs,1-OHP,lncRNAs,HOTAIR,MALAT1,TUG1,GAS5,H2K27me3

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