CASPASE 9 PROMOTER POLYMORPHISMS IN GASTRIC CANCER, MAZANDARAN PROVINCE
Journal of Mazandaran University of Medical Sciences(2013)
摘要
Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter could influence the gene activity and cause sensitivity to cancer. Materials and methods: In this case-control study, 100 patients with gastric cancer and 100 normal subjects were considered for caspase 9 promoter gene polymorphism. DNA extraction was performed from white blood cells according to manufacturer protocol. PCR-RFLP was carried out to detect -712 C>T gene polymorphism. Data was analyzed using SPSS V.18 and P T caspase 9 polymorphism could be a marker in personal sensitivity to gastric cancer and useful in cancer treatment and prevention process.
更多查看译文
关键词
pcr,restriction fragment length polymorphism
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要