Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice

Wenxin Xu, Karen Kage, Warren D Marcus,Robby Newman,Sarah Alter,Peter R Rhode,Hing C Wong

Journal for ImmunoTherapy of Cancer（2015）

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摘要

Meeting abstracts Immune checkpoint therapy, which can target regulatory pathways of T cells to enhance antitumor immune responses, has led to important clinical advances and provides novel strategies for combination immunotherapies against cancer. ALT-803 is an IL-15 superagonist complex capable

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关键词

Bladder Tumor, Immune Checkpoint, Immune Checkpoint Inhibitor, Solid Tumor Model, Include Bladder Cancer

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