Cd4(+) Th1 To The Rescue In Her-2+Breast Cancer

Lea Lowenfeld,Shuwen Xu,Brian J. Czerniecki

ONCOIMMUNOLOGY（2019）

Cited 5|Views18

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Abstract

HER2 overexpression leads to downregulation of MHC class-I. CD4(+) Th1 cytokines, IFN gamma and TNF alpha, and monoclonal antibodies, trastuzumab and pertuzumab, restore MHC class-I expression, and enable CD8(+) recognition and cytolysis. Restoration of the anti-HER2 CD4(+) Th1 immune response in combination with HER2 targeted therapy appear to be critical to successful anti-HER2 CD8(+) immunotherapy.

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Key words

HER2,CD8(+) T-cells,MHC class-I,CD4(+) T-cells,IFN gamma,TNF alpha,monoclonal antibodies,trastuzumab,pertuzumab

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