Measurement of Serum IgE and Monoamine Oxidase in Prurigo Nodularis and Its Clinical Significance

目的：探讨IgE，单胺氧化酶(MAO)在结节性痒疹中的作用。方法：选择确诊的结节性痒疹患者90例及其90例正常人，分别采用直接化学发光法检测其血清总IgE，采用连续监测法测定单胺氧化酶并进行比较。结果：结节性痒疹患者血清总IgE含量高于健康对照组(P < 0.05)，患者血清MAO含量高于健康对照组(P < 0.01)。结论：IgE，MAO参与了结节性痒疹的发病过程，为临床诊断及治疗提供了科学依据。 Objective: To study the role of serum IgE and Monoamine oxidase (MAO) in Prurigo nodularis. Me- thods: 90 cases of Prurigo nodularis patients and 90 healthy controls were selected in the investigation. The total serum IgE were measured by Direct chemiluminescence method. The serum MAO were measured by Continuous monitoring method. Results: The levels of total serum IgE in Prurigo nodularis patients were significantly higher than those in healthy controls (P < 0.05). The levels of serum MAO in Prurigo nodularis patients were significantly higher than those in healthy controls (P < 0.01). Conclusion: Serum IgE, MAO may play a part of role in the pathogenesis of Prurigo nodularis, and the results provide the science views for clinical diagnosis and treatment.