Antimicrobial Activities Of Synthesized Zinc(II) Mixed-Ligand Complexes Derived From 2-Acetylpyridine-4-Phenylsemicarbazone And Nitrogen-Sulphurmonodentate Ligands

The reaction of zinc chloride with 2-acetylpyridine-4-phenylsemicarbazone and nitrogen-sulphurmonodentate ligands such as thiophene, pyridine, picoline ,aniline and ammonia; yielded five novel mixed -ligand complexes: Zn(2-Ac.4-Psc.Th)Cl2 ,Zn(2-Ac.4-Psc.Py)Cl2, Zn(2-Ac.4- Psc.Pi)Cl2, Zn(2Ac.4-Psc.An)Cl2 and Zn(2-Ac.Psc.Am)Cl2. These were characterized by elemental analysis,molar conductivity, 1 H and 13 C-NMR, IR and electronic absorption spectroscopic studies.All the complexes possess tetrahedral geometries. The antimicrobial activities were evaluated against staphylococcus aureus, Bacillus anthracis,Aspergillusnigers andCandida albicans.The result of significant inhibition of growth and proliferation of these microbes by the chelates were obtained particularly with the highest efficiency shown by thethiophene and aniline incorporated complexes