Correlation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) expressions with clinico-pathological features of oral squamous cell carcinoma (OSCC)
Tanta Dental Journal(2015)
Abstract
Oral squamous cell carcinoma (OSCC) is a characteristic aggressiv e tumor representing a significant public health threat all over the world. Up to 50–60% of solid tumors may exhibit hypoxic tissue areas that are heterogeneously distributed within the tumor stroma. Hypoxia inducible factor-1α (HIF-1α) is a central regulator in the adaptive cellular response to hypoxia; however its role is still uncovered. Vascular endothelial growth factor (VEGF) is an important molecule playing crucial role not only in inflammation, but also in angiogenesis and thus tumor growth and progression. So, the aim of this work is to investigate the expression of HIF-1α and VEGF in OSCC and correlate their expressions with clinical and histopathological features of OSCC. In this work, tissue specimens from a total of 45 cases with OSCC were stained immunohistochemically with HIF-1α and VEGF antibodies and examined microscopically.
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Key words
OSCC,HIF-1α,VEGF
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