Induction of systemic anti-melanoma immunity through intratumoral TLR-7/8 activation

Manisha Singh,Hiep Khong,Zhimin Dai,John P Vasilakos,Patrick Hwu,Willem W Overwijk

Journal for ImmunoTherapy of Cancer（2014）

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摘要

Meeting abstracts Intratumoral immune activation can induce systemic immunity and anti-tumor activity. Imiquimod is a cream-formulated, TLR-7 agonist that is FDA-approved for the treatment of non-melanoma skin cancers, but has limited activity against melanoma. In the current study, we studied the

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关键词

Nitric Oxide,Melanoma,Imiquimod,CCL2 Chemokines,Immune Cell Infiltrate

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