Enantioselective metal-free reduction of ketones by a user-friendly silane with a reusable chiral additive

Sami E. Varjosaari,Vladislav Skrypai,Sharon M. Herlugson,Thomas M. Gilbert,Marc J. Adler

Tetrahedron Letters（2018）

引用 6|浏览2

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摘要

•Asymmetric reduction of ketones using easy-to-handle and inexpensive silatrane.•Commercially available 1,2-aminoalcohols served to induce chirality (ees up to 86%).•Chiral additives are used stoichiometrically, but recyclable (with full activity).

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关键词

Hydrosilylation,Asymmetric ketone reduction,Synthesis of chiral alcohols

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