Synovial fluid protein adsorption on polymer-based artificial hip joint material investigated by MALDI-TOF mass spectrometry imaging

Sophie M Frohlich,Victoria Dorrer,Vasilikimaria Archodoulaki,Gunter Allmaier,Martina Marchettideschmann

EuPA Open Proteomics（2014）

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摘要

•Protein adsorption was investigated for UHMWPE hip joint material using synovial fluid as lubricant.•High abundance proteins and especially apolipoproteins subunits were identified on gamma-irradiated and Vitamin E doped UHMWPE using SDS PAGE and mass spectrometry imaging.•Mass spectrometry imaging revealed a homogeneous protein distribution on planar polymer surfaces.•Morphological changes of UHMWPE material, i.e. rough surfaces, lead to enhanced protein cluster formation.

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关键词

PE-UHMW,Protein adsorption,Intact proteins,Mass spectrometry imaging,Synovial fluid,MALDI-TOF

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