ASSESSING ENVIRONMENTAL RISK - SCIENTIFICALLY DEFENSIBLE OR FANTASY

Estimating the risk to human health from synthetic toxic substances is becoming increasingly critical in our society. Epidemiological studies should play a vital role in risk assessment. Without human data based on valid, well-done epidemiological studies, extrapolation from animal studies may seriously overestimate or underestimate the risk. To assess risk to the best of our ability, scientists must use all the data-human and animal-and combine this information with the soundest professional judgment. The multistage linearized model for quantitative risk assessment is not appropriate for all chemicals and just because the results of an epidemiological study have been published, they do not necessarily provide the final answers.