PS19 - 89. Absence of JNK1 protects mice against age-induced obesity and insulin resistance

Pascal Hommelberg,Marcela Aparicio-Vergara,Marijke Schreurs,Niels Kloosterhuis,Marten Hofker,Debby Koonen

Nederlands Tijdschrift voor Diabetologie（2015）

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Abstract

Both a Western-type diet as well as ageing are risk factors for the development of obesity and type 2 diabetes. Dietinduced obesity is associated with an upregulation of stress kinases like c-Jun amino-terminal kinase 1 (JNK1), and JNK1 knockout mice are protected against diet-induced obesity and insulin resistance.

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Key words

Insulin Resistance,Indirect Calorimetry,Insulin Tolerance Test,Bodyweight Gain,Stress Kinase

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