ABCC11 – as key anti-odor target

Background In a previous publication, we showed that the ABCC11 transporter is crucial for the formation of the characteristic axillary odor and that a 538G>A single nucleotide polymorphism (SNP) in the gene, prominent in Asians, leads to a nearly complete loss of the typical sweat odor components in these carriers. As it is unclear, whether ABCC11 is directly involved in the transport of these components, we performed ABCC11-mediated transporter experiments with various potential odor precursors and also studied possible pathways for the formation of these precursors.