Inhibitors Of Cell Cycle Checkpoints And Dna Replication Cause Different Responses In Normal Versus Malignant Urothelial Cells
MOLECULAR & CELLULAR ONCOLOGY(2014)
Abstract
S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed.
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Key words
ATM,cell fate,CHK1,DNA damage response,DNA replication,S-phase checkpoints
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