Perreyia Flavipes Larvae Toxicity

Raymundo D. L., Bezerra Jr P. S., Bandarra P. M., Dalto A. G. C., Soares M. P., Cruz C. E. F. & Driemeier D. 2012. Perreyia flavipes larvae toxicity. Pesquisa Veterinaria Brasileira 32(8): 735-738. Setor de Patologia Veterinaria, Departamento de Patologia Clinica Veterinaria, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Av. Bento Gonalves 9090, Porto Alegre, RS 95320-000, Brazil. E-mail: djeison.raymundo@dmv.ufla.brFresh or thawed Perreyia flavipes larvae were ground and mixed with water and orally ad ministered to sheep. At 5mg/kg, neither clinical nor enzymatic changes were observed. Unique doses of 7.5 and 10mg/kg induced characteristic clinical signs of Perreyia sp. larvae poisoning, increased GGT and AST values, and decreased glycemic curves. However, doses of 5, 10, and 15mg/kg repeated at 30 or 15 days intervals caused no disease and mild disease followed by death, respectively. These findings indicate that these animals probably developed some degree of tolerance to the toxins in P. flavipes larvae. Ultrastructural examination of liver revealed proliferation of the smooth endoplasmic reticulum in the hepatocytes, which may be associated with an increased ability to metabolize toxins and could consequently lead to the tolerance observed in the present study. Further investigations may elucidate whether such tolerance effects could be applied as a control measure for P. flavipes poioning or other hepatotoxic diseases. In addition, clinicopathological findings were discussed.