PS21 - 103. Multipotent pancreatic progenitor cells in 3D culture of human pancreatic ductal tissue: potential relevance for beta cell therapy in Type 1 diabetes

An attractive regenerative medicine approach towards β-cell replacement therapy is the derivation of insulinsecreting cells from stem/progenitor cells. We applied a novel 3-dimensional (3D) matrigel-based culture system to generate human pancreatic tissue (‘pancreatic organoids’) in vitro as a potential source for human β-cells.