The effect of endotoxin adsorber haemoperfusion on microcirculation in septic pigs
Intensive Care Medicine Experimental(2015)
摘要
Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) However, the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown. We used a fecal peritonitis-induced septic pig model to investigate the effect of polymyxin B perfusion on the microcirculation.
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关键词
Polymyxin,Sepsis Group,Continuous Cardiac Output,Microcirculatory Dysfunction,Joint Research Program
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