Prognostic value of post-procedural mean platelet volume on one-year major cardiac outcomes in ST-elevation myocardial infarction after percutaneous coronary intervention

The aim of this study was to investigate the association of mean platelet volume (MPV) with 1-year major cardiac outcomes in ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) and explore its relation with prognosis. Patients (n=301) with a diagnosis of STEMI were divided into 2 groups (G) according to their mean platelet volume (G1≤ 9.9 fl, n=101; G2 > 9.9 fl, n=200) which was measured within 12 hours after PCI. They were followed up for MCO during 1-year. MCO rate was higher in G2 than G1 (25% vs. 13.9%; P=0.026). This difference resulted from differences in recurrent-angina (17.5% vs. 7.9%; P=0.024) and re-hospitalization rates (19.5% vs. 9.9%; P=0.033). In binary logistic regression analysis, high MPV was an independent predictor of MCO (OR 1.30, 95%CL 1.01-1.69, p=0.045). In conclusion, elevated MPV was independently associated with MCO in patients with STEMI after PCI. Moreover, MPV greater than 9.9fl was predictive of 1-year MCO.