Pre-operative immunotherapy with tumor cryoablation (cryo) plus ipilimumab (ipi) induces potentially favorable systemic and intratumoral immune effects in early stage breast cancer (ESBC) patients

David B Page,Adi Diab,Jianda Yuan,Zhiwan Dong,Stephen B Soloman,Sujata Patil,Clifford A Hudis,Jedd D Wolchok,Larry Norton,Heather L McArthur

Journal for ImmunoTherapy of Cancer（2015）

引用 9|浏览8

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摘要

Meeting abstracts In mice, cryo plus checkpoint blockade facilitates tumor antigen release, T-cell priming, and improved survival [[1][1]]. Here, we assess immune response in ESBC patients using biomarkers that have been attributed to clinical benefit following checkpoint blockade [[2][2]–[5][3

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关键词

Breast Cancer,Great Increase,Serial Blood,Tumor Antigen,Ipilimumab

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