Antibodies specific for DKK-1

Zhiqiang An,Fang Chen,John E Fisher,Helmut Glantschnig,Donald B Kimmel,Alfred A Reszka,Fubao Wang

mag（2008）

引用 28|浏览33

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摘要

Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.

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关键词

Wnt signaling pathway,Signal transduction,Osteoporosis,Medicine,LRP5,Immunology,Cancer research,Bone growth,Antibody

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