IL-6-174G/C及CRP+1059G/C基因多态性与新疆哈萨克族代谢综合征及其组分的相关性研究
mag(2010)
Abstract
为探讨IL-6-174G/ C及CRP+1059G/C基因多态性与新疆哈萨克族代谢综合征(MS)及其组分的相关性.应用PCR-RFLP方法对新疆哈萨克族MS病例组200例及对照组201例的白细胞介素6基因-174G/C位点及CRP基因+1059G/C位点进行检测.IL-6-174G/ C位点MS组与对照组均以GG基因型为主,其频率分别为94%和98.5%, GC基因型频率分别为6.0%和1.5%,CC型在MS组有1例,占0.5%,在对照组未发现.G和C等位基因频率在MS组分别为97.0%和3.0%,两组基因型差异有统计学意义(χ2=5.66,P<0.05)两组间等位基因频率差异有统计学意义(χ2=6.43,P<0.05);CRP+1059G/C位点MS组与对照组以GG基因型为主,其频率分别为93.0%和99.0%,GC基因型频率在两组分别为7.0% 和1.0%,CC纯合子基因型在两组中均未检出.G和C等位基因频率在MS组分别为96.5%和3.5%,两组基因型差异有统计学意义(χ2=9.43,P<0.05),两组等位基因频率差异有统计学意义(χ2=9.24,P<0.05).IL-6-174G/C和CRP+1059G/C基因多态性与哈萨克族代谢综合征及组分有一定关联.
MoreKey words
IL-6-174G/C,CRP+1059G/C
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