Cd4(+) T Helper Cell Responses To Ny-Eso-1 Tumor Antigen In Ovarian Cancer Resist Perversion Into Immunosuppressive Tregs

In a recent study, we have demonstrated that T helper type 1 (TH1) cells specific for the tumor antigen NY-ESO-1 are amplified at ovarian tumor sites but are not "perverted" into immunosuppressive FOXP3(+) regulatory T cells (Tregs). These findings encourage the development of protocols aiming to eliminate, or inactivate, FOXP3(+) Tregs and reinforce Type I anticancer immunity, to improve clinical outcomes.