Synthesis of hybrids compounds by Click Chemistry and their bioactivities

In this work, a collection of hybrid compounds of type 1 (Scheme 1) were synthesized by a convergent route as potential anthelmintic drugs. One fragment of the hybrids is an oxazole or thiazole prepared from a serine dipeptide. The other domain, are a dihydropyran obtained by Prins’s cyclization, functionally with ethynyl moiety by Corey-Fusch reaction. Both heterocycles were coupled using the Huisgen´s reaction by a triazol. Cytotoxicity of hybrids were evaluated by seven cellular lines and anthelmintic activity by Nippostrongilus brasiliensis assay.