Current Concepts in the Treatment of Autoimmune Diseases with Monoclonal Antibodies

Evelyne Racadot,Daniel Wendling,Lucien Rumbach,John Wijdenes,P Herve

Clinical Immunotherapeutics（2012）

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摘要

Monoclonal antibodies (mAbs) have been used in a wide variety of autoimmune diseases, most particularly in rheumatoid arthritis and multiple sclerosis. Activation antigens (interleukin-2 receptor), pan-T cell antigens (CD2 and CD3), and T cell subset-specific antigens (CD4) are the most commonly recognised targets of mAbs.

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关键词

Rheumatoid Arthritis, Multiple Sclerosis, Experimental Allergic Encephalomyelitis, Activation Antigen, Matoid Arthritis

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