Specific IgE to Ara h 2 is the best predictor for peanut allergy in adults and is correlated to clinical severity

Background Specific IgE to Ara h 2 as clinical predictor for peanut allergy in children has a diagnostic value comparable to a recently published prediction model containing gender, skin prick test (SPT), specific IgE (sIgE) to peanut extract and total IgE. The need for food challenges could be reduced by implicating both methods. In adults, the diagnostic value of peanut components has not been studied yet. Our aim was to validate in an adult population the published prediction model and in case of poor validation, build a new model specific for adults. In addition, to define the diagnostic value of sIgE to peanut components and their correlation to clinical severity.