Combined Effect Of Low-Frequency High-Intensity Ultrasound And Streptokinase On The Efficiency Of Thrombi Destruction

Results of numerous experimental studies indicate that low-intensity ultrasound (US) intensifies the drug induced fibrinolysis. However, exits opinion, what high-intensity ultrasound could be not recommending for use in combination with thrombolytic agents due to the transience of exposure of thrombus to ultrasound and relatively low speed of the enzymatic process. We also hypothesise that high-intensity low-frequency US can accelerate the drug induced fibrinolysis. During in vitro studies, we showed that the administration of streptokinase (SK) prevents the formation of particle conglomerates resulting due to destruction of fibrin clots by using low-frequency high-intensity US. In addition, it was established that in conditions of the combined effect of streptokinase and high-intensity US, the process of acoustic-mechanical destruction of thrombus is prevailing, and the fibrinolytic effect of streptokinase is generally witnessed after the termination of US and manifests itself in enzymatic lysis of both resultant particles and residual clot mass. In this study we verified the effect of low-frequency high-intensity ultrasound on the dynamics and efficiency of fibrinolysis induced by streptokinase on various structure thrombi model, characteristic features of the fibrin clot network structure occurring during the combined effect of ultrasound and streptokinase.