The Biocompatibility Of Electrospun Wool Polypeptide/Plla Composite Nanofibers On Saos-2 Osteoblasts

The electrospun wool polypeptides/PLLA composite nanofibers were investigated in vitro using human osteoblast like cells (Saos-2). Cell morphology, cell proliferation and cell differentiation on the composite nanofibers were evaluated and compared with PLLA nanofibers. The results indicated that the composite nanofibers improve the cell seeding density and cell spreading efficiency of Saos-2. The differentiation of osteoblasts are enhanced by the composite nanofibers in terms of the increased expressions of osteocalcin and procollagen type I peptides. These cell responses suggested a promising application of the wool polypeptides as a complementary composite combined with PLLA nanofibers.