Chronic eosinophilic leukemia transformation into acute myeloid leukemia with monocytic differentiation

We present a rare case of a patient that presented with a highly elevated total leukocytic count, abnormally high eosinophils and increased number of blasts that was diagnosed as chronic eosinophilic leukemia. The blast cell count did not reach the threshold to diagnose acute leukemia. Over 6 months, the case progressed to acute myeloid leukemia with normal total leukocyte count but high percentage of blast cells and decreased percentage of eosinophils.