Catalytic in vivo protein knockdown by small-molecule PROTACsDaniel P Bondeson,Alina Mares,Ian E D Smith,Eunhwa Ko,Sebastien Campos,Afjal H Miah, Katie E Mulholland, Natasha Routly,Dennis L Buckley,Jeffrey L Gustafson,Nico Zinn,Paola Grandi,Satoko Shimamura,Giovanna Bergamini,Maria Faelth-Savitski,Marcus Bantscheff,Carly Cox,Deborah A Gordon,Ryan R Willard,John J Flanagan,Linda N Casillas,Bartholomew J Votta,Willem den Besten, Kristoffer Famm,Laurens Kruidenier,Paul S Carter,John D Harling,Ian Churcher,Craig M CrewsNature Chemical Biology（2015）引用 732|浏览11暂无评分摘要The use of a high-affinity VHL ligand allows the development of chimeric molecules that promote the association of ERRα or RIPK2 with the VHL E3 ubiquitin ligase complex, resulting in protein degradation.更多查看译文关键词pharmacology,proteomics,small moleculesAI 理解论文溯源树样例生成溯源树，研究论文发展脉络Chat Paper正在生成论文摘要
