Microfluidic immunophenotyping assay platform for immunomonitoring of subpopulations of immune cells

Functional immunophenotyping of immune cells is a promising method for diagnosis of immune dysfunctions. In this study, an integrated microfluidic immunophenotyping device was developed that could achieve rapid and efficient isolation, enrichment, stimulation and functional immunophenotyping of subpopulations of immune cells directly from blood specimens. This new microfluidic immunophenotyping technology can provide an unprecedented level of information depth on the distribution of immune cell functionalities. Such an innovative tool will allow comprehensive and systems-level immunomonitoring to define and characterize the “immune status” of healthy individuals and patients, critical for clinical interventions and managements of patients with immune system disorders.