Ultrasound and microbubbles for treatment purposes: mechanisms and results
Clinical and Translational Imaging(2014)
Abstract
The need to improve local drug and gene delivery, to increase their efficacy and safety, has prompted scientists to investigate different approaches. One of the most promising has been the combination of ultrasound and microbubbles, which can act as a local enhancer of this delivery. Even though the exact mechanism has not been fully elucidated, close contact between the bubbles and cell membrane is required to induce pore formation or endocytosis prior to secondary transfer of the molecule of interest into the cell. The literature contains a wealth of papers that have clearly demonstrated the efficiency of this approach in animal models. The clinical effectiveness of microbubble-mediated treatment demonstrated in sonothrombolysis will likely open up new treatment opportunities in refractory diseases or the possibility of developing new means of delivering molecules in poorly accessible tissues, such as brain tissue.
MoreTranslated text
Key words
Sonoporation,Drug delivery,Gene delivery,Ultrasound,Sonothrombolysis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined