泛发性脓疱型银屑病患者皮损处IL-8及GM-CSF的检测
China journal of Leprosy and Skin Diseases(2011)
Abstract
目的:研究泛发性脓疱型银屑病患者皮损中白介素8(IL-8)和粒细胞-巨噬细胞集落刺激因子( GM - CSF)水平.方法:用免疫组化方法检测泛发性脓疱型银屑病患者皮损中IL-8和GM- CSF的水平并与进展期寻常型银屑病患者及正常人群进行比较,进一步探讨IL-8和GM- CSF与泛发性脓疱型银屑病发病机制的相关性.结果:泛发性脓疱型银屑病组皮损处IL-8水平和GM-CSF水平与进展期寻常型银屑病组及正常对照组相比显著升高(P< 0.05).二者浓度呈正相关(R=0.896,P≤0.05).结论:IL-8和GM- CSF可能与泛发性脓疱型银屑病的发病机制有关.
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