Imidazopyridyl compounds as aldosterone synthase inhibitors.

Brent R Whitehead,Michael M-C Lo,Amjad Ali,Min K Park,Scott B Hoyt,Yusheng Xiong,Jiaqiang Cai, Emma Carswell,Andrew Cooke,John MacLean,Paul Ratcliffe,John Robinson,D Jonathan Bennett, Joseph A Clemas,Tom Wisniewski,Mary Struthers,Doris Cully,Douglas J MacNeil

Bioorganic & Medicinal Chemistry Letters（2017）

引用 32|浏览7

暂无评分

摘要

The inhibition of aldosterone synthase (CYP11B2) may be an effective treatment of hypertension and heart failure, among other ailments. Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.

查看译文

关键词

Aldosterone,CYP11B2,Hypertension,Imidazopyridine,Heart failure

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要