海洋来源真菌Aspergillus sp.SCSIO 81-F2抗菌活性次级代谢产物的研究
Natural Product Research and Development（2015）
Abstract
采用抑菌活性追踪的方法,利用硅胶柱色谱和半制备反相高效液相色谱法对一株南海海洋来源真菌SCSIO 81-F2的发酵产物进行分离,纯化获得3个单体化合物,通过理化性质、MS、NMR及X-单晶衍射分析,分别鉴定为xanthocillin X dimethylether(1)、xanthocillin X monomethylether(2)、6',8'-dimethoxy xanthocillin X dimethylether(3).经18S rDNA序列分析并构建系统发育进化树,鉴定该菌株为曲霉属真菌Aspergillus sp.SCSIO 81-F2.海洋曲霉菌Aspergillus sp.SCSIO 81-F2是一个能产生具有抗菌活性xanthocillin类抗生素的新来源.
MoreKey words
Xanthocillin X,marine fungus,Aspergillus,secondary metabolites
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