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In Vitro and In Vivo Inhibitory Effects of Interferon α 2b on CML Granuloerythroid Precursors

A. Sandrelli,P. De Fabritiis,G. Meloni,A. Cafolla,F. Simone,G. Di Matteo,M. Nanni, F. Mandelli

Cytokines in Hemopoiesis, Oncology, and AIDS（1990）

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Abstract
Chronic myelogenous leukemia (CML) is a clonal hemopathy in which malignant transformation probably occurs in an early hemopoietic precursor cell. The initial chronic phase is easily treated by chemotherapy, but the fatal course of the disease rapidly evolves into the acute phase that is very difficult to control with conventional drugs.
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Key words
Chronic Myeloid Leukemic Cell, Hematological Remission, Hemopoietic Precursor, Hemopoietic Precursor Cell, Stern Cell
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