2,4,5-三氟苯乙酸的合成研究进展
Chemical Research and Application（2014）
Abstract
2,4,5-三氟苯乙酸是二肽基肽酶-IV抑制剂类糖尿病治疗药物西他列汀的关键中间体,本文总结并评述了2,4,5-三氟苯乙酸的合成方法。
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Key words
sitagliptin,5-trifluorophenylacetic acid,Grignard addition,Grignard coupling,nucleophilic substitution
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