Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin

Rastislav Jendželovský,Zuzana Jendželovska,Lucia Hiľovska,Jan Kovaľ,Jaromir Mikes,Peter Fedorocko

Toxicology Letters（2016）

引用 11|浏览11

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摘要

•Proadifen potentiated the effect of cisplatin in resistant ovarian cancer cells.•Proadifen decreased the levels of reduced glutathione primarily in A2780cis cells.•Proadifen inhibited the activity of MRP1 and MRP2 primarily in A2780cis cells.•Proadifen inhibited the expression of survivin in A2780cis cells.

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关键词

Proadifen,Cisplatin,MRP1,MRP2,Glutathione,Survivin

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