Influence of Liver and Renal Function in Systemic Mild Hypothermia Technique to the Multiple Organ Dysfunction Syndrome in Children

目的：通过全身亚低温治疗多器官功能障碍综合征(MODS)患儿，探讨全身亚低温技术对MODS患儿肝肾功能的影响。方法：将36例患儿随机分为全身亚低温治疗组(亚低温组，HT组，19例)和常规治疗组(对照组，NT组，17例)。分别于亚低温治疗前及治疗后第12 h、24 h、36 h时间点采集外周静脉血检测并记录两组患儿肝肾功能的变化。结果：HT组与NT组治疗前丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)比较无统计学差异(P > 0.05)；治疗后36 h ALT两组相比差异具有统计学意义(P 0.05)。HT组与NT组治疗前肌酐(CR)、尿素氮(BUN)比较无统计学差异(P > 0.05)；治疗后36 h两组CR、BUN相比差异具有统计学意义(P 0.05); the level of ALT, CR and BUN in 36 h had obvious statistical difference comparing to the before (P < 0.05), and the HT group than normal temperature NT group; while no significant difference compared to AST in 36 h. Conclusion: The systemic mild hypothermia had significant liver and renal function-protective effects in MODS children patients.